› 2a8b

X-ray diffraction
2.3Å resolution

Crystal Structure of the Catalytic Domain of Human Tyrosine Phosphatase Receptor, Type R

Released:
DOI: 10.2210/pdb2a8b/pdb
PDB entry 2a8b coloured by chain, front view.
PDB entry 2a8b coloured by chain, side view.
PDB entry 2a8b coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.
Eswaran J, von Kries JP, Marsden B, Longman E, Debreczeni JE, Ugochukwu E, Turnbull A, Lee WH, Knapp S, Barr AJ
Biochem J 395 483-91 (2006)
PMID: 16441242

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172237 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-type tyrosine-protein phosphatase R Chain: A
Molecule details ›
Chain: A
Length: 283 amino acids
Theoretical weight: 32.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15256 (Residues: 375-655; Coverage: 44%)
Gene names: ECPTP, PTPRQ, PTPRR
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

1 bound ligand:
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21212
Unit cell:
a: 63.193Å b: 74.098Å c: 62.328Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.192 0.256
Expression system: Escherichia coli BL21(DE3)

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Citations

12 review citations

Therapeutic implications for striatal-enriched protein tyrosine phosphatase (STEP) in neuropsychiatric disorders.
Goebel-Goody et al. (2012)
11 more

6 mentions without citation

Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Barr et al. (2009)
5 more