1zz2 Summary

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Two Classes of p38alpha MAP Kinase Inhibitors Having a Common Diphenylether Core but Exhibiting Divergent Binding Modes

The structure was published by Michelotti, E.L., Moffett, K.K., Nguyen, D., et al., Bukhtiyarova, M., Springman, E.B., and Karpusas, M., in 2005 in a paper entitled "Two classes of p38alpha MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 336 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) protein kinase activitysearch ATP bindingsearch nucleotide bindingsearch MAP kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch protein serine/threonine kinase activitysearch MAP kinase kinase activitysearch NFAT protein bindingsearch kinase activitysearch transferase activitysearch MAPK cascadesearch cellular response to ionizing radiationsearch activation of MAPK activitysearch 3'-UTR-mediated mRNA stabilizationsearch toll-like receptor 4 signaling pathwaysearch angiogenesissearch response to stresssearch toll-like receptor 9 signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch protein phosphorylationsearch blood coagulationsearch toll-like receptor TLR1:TLR2 signaling pathwaysearch neurotrophin TRK receptor signaling pathwaysearch cell surface receptor signaling pathwaysearch toll-like receptor 5 signaling pathwaysearch striated muscle cell differentiationsearch skeletal muscle tissue developmentsearch positive regulation of blood vessel endothelial cell migrationsearch mRNA metabolic processsearch positive regulation of protein import into nucleussearch regulation of transcription, DNA-dependentsearch chemotaxissearch intracellular protein kinase cascadesearch response to DNA damage stimulussearch MyD88-dependent toll-like receptor signaling pathwaysearch toll-like receptor 10 signaling pathwaysearch response to muramyl dipeptidesearch signal transduction in response to DNA damagesearch peptidyl-serine phosphorylationsearch toll-like receptor 3 signaling pathwaysearch phosphorylationsearch osteoclast differentiationsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch cellular response to vascular endothelial growth factor stimulussearch signal transductionsearch platelet activationsearch toll-like receptor signaling pathwaysearch chondrocyte differentiationsearch toll-like receptor 2 signaling pathwaysearch vascular endothelial growth factor receptor signaling pathwaysearch TRIF-dependent toll-like receptor signaling pathwaysearch gene expressionsearch positive regulation of erythrocyte differentiationsearch fatty acid oxidationsearch positive regulation of reactive oxygen species metabolic processsearch DNA damage checkpointsearch positive regulation of muscle cell differentiationsearch transcription, DNA-dependentsearch Ras protein signal transductionsearch RNA metabolic processsearch cell morphogenesissearch cellular component movementsearch stress-activated MAPK cascadesearch glucose metabolic processsearch lipopolysaccharide-mediated signaling pathwaysearch muscle cell differentiationsearch innate immune responsesearch positive regulation of transcription from RNA polymerase II promotersearch regulation of sequence-specific DNA binding transcription factor activitysearch response to lipopolysaccharidesearch apoptotic processsearch stress-induced premature senescencesearch cytosolsearch nucleoplasmsearch cytoplasmsearch mitochondrionsearch spindle polesearch nucleussearch cellsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine- / dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch