1zz2 Summary


Two Classes of p38alpha MAP Kinase Inhibitors Having a Common Diphenylether Core but Exhibiting Divergent Binding Modes

The structure was published by Michelotti, E.L., Moffett, K.K., Nguyen, D., et al., Bukhtiyarova, M., Springman, E.B., and Karpusas, M., in 2005 in a paper entitled "Two classes of p38alpha MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 336 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) ATP bindingsearch MAP kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein bindingsearch protein kinase activitysearch nucleotide bindingsearch transferase activitysearch NFAT protein bindingsearch kinase activitysearch protein serine/threonine kinase activitysearch MAP kinase kinase activitysearch protein phosphorylationsearch chondrocyte differentiationsearch angiogenesissearch MyD88-dependent toll-like receptor signaling pathwaysearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch MyD88-independent toll-like receptor signaling pathwaysearch negative regulation of canonical Wnt signaling pathwaysearch toll-like receptor TLR1:TLR2 signaling pathwaysearch muscle cell differentiationsearch DNA damage checkpointsearch skeletal muscle tissue developmentsearch glucose metabolic processsearch neurotrophin TRK receptor signaling pathwaysearch cellular response to lipopolysaccharidesearch p38MAPK cascadesearch myoblast differentiation involved in skeletal muscle regenerationsearch positive regulation of transcription from RNA polymerase II promotersearch toll-like receptor signaling pathwaysearch response to lipopolysaccharidesearch toll-like receptor 5 signaling pathwaysearch toll-like receptor 10 signaling pathwaysearch positive regulation of myoblast differentiationsearch response to stresssearch positive regulation of myotube differentiationsearch regulation of sequence-specific DNA binding transcription factor activitysearch positive regulation of myoblast fusionsearch peptidyl-serine phosphorylationsearch cell surface receptor signaling pathwaysearch toll-like receptor 2 signaling pathwaysearch apoptotic processsearch signal transduction in response to DNA damagesearch TRIF-dependent toll-like receptor signaling pathwaysearch platelet activationsearch chemotaxissearch gene expressionsearch blood coagulationsearch toll-like receptor 3 signaling pathwaysearch cellular component movementsearch stress-activated MAPK cascadesearch toll-like receptor 4 signaling pathwaysearch cellular response to ionizing radiationsearch osteoclast differentiationsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch RNA metabolic processsearch positive regulation of muscle cell differentiationsearch regulation of transcription from RNA polymerase II promotersearch vascular endothelial growth factor receptor signaling pathwaysearch Ras protein signal transductionsearch cellular response to vascular endothelial growth factor stimulussearch cell morphogenesissearch phosphorylationsearch innate immune responsesearch fatty acid oxidationsearch cellular response to DNA damage stimulussearch positive regulation of erythrocyte differentiationsearch 3'-UTR-mediated mRNA stabilizationsearch positive regulation of protein import into nucleussearch activation of MAPK activitysearch toll-like receptor 9 signaling pathwaysearch regulation of transcription, DNA-templatedsearch transcription, DNA-templatedsearch stress-induced premature senescencesearch mRNA metabolic processsearch striated muscle cell differentiationsearch intracellular signal transductionsearch cartilage condensationsearch response to muramyl dipeptidesearch signal transductionsearch positive regulation of reactive oxygen species metabolic processsearch positive regulation of blood vessel endothelial cell migrationsearch lipopolysaccharide-mediated signaling pathwaysearch cytosolsearch nucleoplasmsearch cytoplasmsearch nucleussearch cellsearch spindle polesearch extracellular vesicular exosomesearch mitochondrionsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch