1zym Summary



The structure was published by Liao, D.I., Silverton, E., Seok, Y.J., Lee, B.R., Peterkofsky, A., and Davies, D.R., in 1996 in a paper entitled "The first step in sugar transport: crystal structure of the amino terminal domain of enzyme I of the E. coli PEP: sugar phosphotransferase system and a model of the phosphotransfer complex with HPr." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1996.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of ENZYME I.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A ENZYME I P08839 (1-258) (PT1_ECOLI)search Escherichia coli K-12search 100% 258 96%
B ENZYME I P08839 (1-258) (PT1_ECOLI)search Escherichia coli K-12search 100% 258 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P08839 (1 - 258) ENZYME I Escherichia coli

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P08839) Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domainsearch, N-terminal domain of enzyme I of the PEP:sugar phosphotransferase systemsearch Phosphohistidine domains of PEP-utilising enzymessearch, Enzyme I, chain A, domain 2search PF00391: PEP-utilising enzyme, mobile domainsearch, PF02896: PEP-utilising enzyme, TIM barrel domainsearch, PF05524: PEP-utilising enzyme, N-terminalsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P08839) transferase activity, transferring phosphorus-containing groupssearch phosphorylationsearch phosphoenolpyruvate-dependent sugar phosphotransferase systemsearch

Chain InterPro annotation
A, B Phosphoenolpyruvate-utilising enzymesearch PEP-utilising enzyme, mobile domainsearch Phosphotransferase system, enzyme I N-terminalsearch PEP-utilising enzyme, active sitesearch