1zyj Summary


Human P38 MAP Kinase in Complex with Inhibitor 1a

The structure was published by Michelotti, E.L., Moffett, K.K., Nguyen, D., et al., Bukhtiyarova, M., Springman, E.B., and Karpusas, M., in 2005 in a paper entitled "Two classes of p38alpha MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 331 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (1-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 91%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (1 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q16539) Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) MAP kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein kinase activitysearch protein bindingsearch kinase activitysearch MAP kinase kinase activitysearch protein serine/threonine kinase activitysearch nucleotide bindingsearch transferase activitysearch NFAT protein bindingsearch protein phosphorylationsearch toll-like receptor 4 signaling pathwaysearch mRNA metabolic processsearch regulation of transcription from RNA polymerase II promotersearch muscle cell differentiationsearch positive regulation of reactive oxygen species metabolic processsearch striated muscle cell differentiationsearch MyD88-independent toll-like receptor signaling pathwaysearch Ras protein signal transductionsearch positive regulation of erythrocyte differentiationsearch skeletal muscle tissue developmentsearch activation of MAPK activitysearch fatty acid oxidationsearch blood coagulationsearch osteoclast differentiationsearch gene expressionsearch platelet activationsearch positive regulation of myotube differentiationsearch cellular response to vascular endothelial growth factor stimulussearch negative regulation of canonical Wnt signaling pathwaysearch stress-activated MAPK cascadesearch positive regulation of muscle cell differentiationsearch p38MAPK cascadesearch phosphorylationsearch positive regulation of myoblast differentiationsearch RNA metabolic processsearch positive regulation of protein import into nucleussearch peptidyl-serine phosphorylationsearch toll-like receptor 5 signaling pathwaysearch angiogenesissearch lipopolysaccharide-mediated signaling pathwaysearch MyD88-dependent toll-like receptor signaling pathwaysearch apoptotic processsearch toll-like receptor signaling pathwaysearch cellular response to ionizing radiationsearch chemotaxissearch regulation of sequence-specific DNA binding transcription factor activitysearch positive regulation of transcription from RNA polymerase II promotersearch toll-like receptor 2 signaling pathwaysearch toll-like receptor 10 signaling pathwaysearch toll-like receptor TLR1:TLR2 signaling pathwaysearch cellular response to DNA damage stimulussearch DNA damage checkpointsearch response to stresssearch cellular response to lipopolysaccharidesearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch TRIF-dependent toll-like receptor signaling pathwaysearch signal transductionsearch cell surface receptor signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch cartilage condensationsearch neurotrophin TRK receptor signaling pathwaysearch positive regulation of myoblast fusionsearch innate immune responsesearch response to muramyl dipeptidesearch cellular component movementsearch signal transduction in response to DNA damagesearch stress-induced premature senescencesearch intracellular signal transductionsearch cell morphogenesissearch toll-like receptor 9 signaling pathwaysearch response to lipopolysaccharidesearch myoblast differentiation involved in skeletal muscle regenerationsearch positive regulation of blood vessel endothelial cell migrationsearch vascular endothelial growth factor receptor signaling pathwaysearch transcription, DNA-templatedsearch 3'-UTR-mediated mRNA stabilizationsearch regulation of transcription, DNA-templatedsearch glucose metabolic processsearch chondrocyte differentiationsearch toll-like receptor 3 signaling pathwaysearch cytoplasmsearch nucleoplasmsearch cytosolsearch cellsearch nucleussearch extracellular vesicular exosomesearch mitochondrionsearch spindle polesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch