› 1zxq

X-ray diffraction
2.2Å resolution

THE CRYSTAL STRUCTURE OF ICAM-2

Released:
DOI: 10.2210/pdb1zxq/pdb
PDB entry 1zxq coloured by chain, front view.
PDB entry 1zxq coloured by chain, side view.
PDB entry 1zxq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface.
Casasnovas JM, Springer TA, Liu JH, Harrison SC, Wang JH
Nature 387 312-5 (1997)
PMID: 9153399

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146670 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Intercellular adhesion molecule 2 Chain: A
Molecule details ›
Chain: A
Length: 192 amino acids
Theoretical weight: 21.38 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P13598 (Residues: 25-216; Coverage: 77%)
Gene name: ICAM2
Sequence domains: Intercellular adhesion molecule (ICAM), N-terminal domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 69Å b: 63.7Å c: 76.2Å
α: 90° β: 114.5° γ: 90°
R-values:
R R work R free
0.226 0.226 0.295
Expression system: Cricetulus griseus

Quick links

Citations

11 review citations

Structural basis of integrin regulation and signaling.
Luo et al. (2007)
10 more

14 mentions without citation

Function and 3D structure of the N-glycans on glycoproteins.
Nagae et al. (2012)
13 more