1zsa Summary

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CARBONIC ANHYDRASE II MUTANT E117Q, APO FORM

The structure was published by Huang, C.C., Lesburg, C.A., Kiefer, L.L., Fierke, C.A., and Christianson, D.W., in 1996 in a paper entitled "Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1996.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 256 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE II P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) CARBONIC ANHYDRASE II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P00918) response to pHsearch kidney developmentsearch bicarbonate transportsearch positive regulation of osteoclast differentiationsearch regulation of intracellular pHsearch positive regulation of cellular pH reductionsearch response to steroid hormonesearch secretionsearch positive regulation of dipeptide transmembrane transportsearch positive regulation of synaptic transmission, GABAergicsearch small molecule metabolic processsearch response to estrogensearch response to organic substancesearch morphogenesis of an epitheliumsearch regulation of chloride transportsearch regulation of anion transportsearch response to zinc ionsearch positive regulation of bone resorptionsearch angiotensin-activated signaling pathwaysearch odontogenesis of dentin-containing toothsearch cytoplasmsearch plasma membranesearch extracellular vesicular exosomesearch cytosolsearch axonsearch microvillussearch membranesearch myelin sheathsearch basolateral plasma membranesearch apical part of cellsearch extracellular spacesearch metal ion bindingsearch carbonate dehydratase activitysearch zinc ion bindingsearch lyase activitysearch protein bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch