1zrz Summary

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Crystal Structure of the Catalytic Domain of Atypical Protein Kinase C-iota

The structure was published by Messerschmidt, A., Macieira, S., Velarde, M., et al., Brandstetter, H., Neuefeind, T., and Blaesse, M., in 2005 in a paper entitled "Crystal Structure of the Catalytic Domain of Human Atypical Protein Kinase C-iota Reveals Interaction Mode of Phosphorylation Site in Turn Motif" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Protein kinase C, iota. This molecule has the UniProt identifier P41743 (KPCI_HUMAN)search. The sample contained 364 residues which is < 90% of the natural sequence. Out of 364 residues 300 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Protein kinase C, iota P41743 (233-596) (KPCI_HUMAN)search Homo sapienssearch < 90% 364 85%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P41743 (233 - 596) Protein kinase C, iota Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch, Protein kinase C terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (P41743) ATP bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch AGC-kinase, C-terminalsearch Serine/threonine- / dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Protein kinase, C-terminalsearch