› 1zrz

X-ray diffraction
3Å resolution

Crystal Structure of the Catalytic Domain of Atypical Protein Kinase C-iota

Released:
DOI: 10.2210/pdb1zrz/pdb
PDB entry 1zrz coloured by chain, front view.
PDB entry 1zrz coloured by chain, side view.
PDB entry 1zrz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif.
Messerschmidt A, Macieira S, Velarde M, Bädeker M, Benda C, Jestel A, Brandstetter H, Neuefeind T, Blaesse M
J Mol Biol 352 918-31 (2005)
PMID: 16125198

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154422 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein kinase C iota type Chain: A
Molecule details ›
Chain: A
Length: 364 amino acids
Theoretical weight: 42 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P41743 (Residues: 233-596; Coverage: 61%)
Gene names: DXS1179E, PRKCI
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand BI1 1 x BI1
1 modified residue:
Ligand TPO 2 x TPO

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P3221
Unit cell:
a: 78.143Å b: 78.143Å c: 112.625Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.249 0.249 0.333
Expression system: Spodoptera frugiperda

Quick links

Citations

14 review citations

Structural basis of protein kinase C isoform function.
Steinberg SF. (2008)
13 more

14 mentions without citation

Substrate and docking interactions in serine/threonine protein kinases.
Goldsmith et al. (2007)
13 more