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E. coli Methylenetetrahydrofolate Reductase (oxidized)

X-ray diffraction
1.85Å resolution
PDB entry 1zp3 coloured by chain, front view.
PDB entry 1zp3 coloured by chain, side view.
PDB entry 1zp3 coloured by chain, top view.
Source organism: Escherichia coli
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: 5,10-methylenetetrahydrofolate reductase
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Multimeric state: homo dimer
Accessible surface area: 22866.21 Å2
Buried surface area: 6419.23 Å2
Dissociation area: 1,297.63 Å2
Dissociation energy (ΔGdiss): 5.75 kcal/mol
Dissociation entropy (TΔSdiss): 13.27 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-142675
Assembly 2
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Assembly Name: 5,10-methylenetetrahydrofolate reductase
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Multimeric state: homo dimer
Accessible surface area: 22866.21 Å2
Buried surface area: 6419.23 Å2
Dissociation area: 1,297.63 Å2
Dissociation energy (ΔGdiss): 5.75 kcal/mol
Dissociation entropy (TΔSdiss): 13.27 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-142675
Assembly 3 (preferred)
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Assembly Name: 5,10-methylenetetrahydrofolate reductase
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Multimeric state: homo dimer
Accessible surface area: 23563.26 Å2
Buried surface area: 7802.86 Å2
Dissociation area: 2,126.02 Å2
Dissociation energy (ΔGdiss): 15.46 kcal/mol
Dissociation entropy (TΔSdiss): 13.62 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-142675

Macromolecules

5,10-methylenetetrahydrofolate reductase
Chains: A, B, C
Length: 304 amino acids
Theoretical weight: 34.22 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P0AEZ1 (Residues: 1-296; Coverage: 100%)
Gene names: JW3913, b3941, metF
Pfam: Methylenetetrahydrofolate reductase
InterPro:
CATH: TIM Barrel
5,10-methylenetetrahydrofolate reductase in PDB entry 1zp3, assembly 3, front view.
5,10-methylenetetrahydrofolate reductase in PDB entry 1zp3, assembly 3, side view.
5,10-methylenetetrahydrofolate reductase in PDB entry 1zp3, assembly 3, top view.
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