1znh Summary


Strong Solute-Solute Dispersive Interactions in a Protein-Ligand Complex

The structure was published by Malham, R., Johnstone, S., Bingham, R.J., et al., Phillips, S.E., Laughton, C.A., and Homans, S.W., in 2005 in a paper entitled "Strong Solute-Solute Dispersive Interactions in a Protein-Ligand Complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Major Urinary Protein. This molecule has the UniProt identifier P11589 (MUP2_MOUSE)search. The sample contained 174 residues which is 100% of the natural sequence. Out of 174 residues 157 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Major Urinary Protein P11589 (19-180) (MUP2_MOUSE)search Mus musculussearch 100% 174 90%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P11589 (19 - 180) Major Urinary Protein Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P11589) Retinol binding protein-likesearch Lipocalinsearch PF00061: Lipocalin / cytosolic fatty-acid binding protein familysearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P11589) small molecule bindingsearch transporter activitysearch pheromone bindingsearch insulin-activated receptor activitysearch positive regulation of protein kinase B signalingsearch negative regulation of lipid biosynthetic processsearch positive regulation of gene expressionsearch transportsearch negative regulation of insulin secretion involved in cellular response to glucose stimulussearch negative regulation of transcription, DNA-templatedsearch energy reserve metabolic processsearch negative regulation of lipid storagesearch insulin receptor signaling pathwaysearch positive regulation of glucose metabolic processsearch mitochondrion morphogenesissearch locomotor rhythmsearch negative regulation of gluconeogenesissearch cellular response to lipidsearch heat generationsearch glucose homeostasissearch aerobic respirationsearch positive regulation of lipid metabolic processsearch extracellular regionsearch cytosolsearch extracellular spacesearch nucleussearch

Chain InterPro annotation
A Lipocalin/cytosolic fatty-acid binding domainsearch Lipocalinsearch Major urinary proteinsearch Calycin-likesearch Calycinsearch Lipocalin family conserved sitesearch