1zng Summary


Strong Solute-Solute Dispersive Interactions in a Protein-Ligand Complex

The structure was published by Malham, R., Johnstone, S., Bingham, R.J., et al., Phillips, S.E., Laughton, C.A., and Homans, S.W., in 2005 in a paper entitled "Strong Solute-Solute Dispersive Interactions in a Protein-Ligand Complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Major Urinary Protein. This molecule has the UniProt identifier P11589 (MUP2_MOUSE)search. The sample contained 174 residues which is 100% of the natural sequence. Out of 174 residues 157 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Major Urinary Protein P11589 (19-180) (MUP2_MOUSE)search Mus musculussearch 100% 174 90%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P11589 (19 - 180) Major Urinary Protein Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P11589) Retinol binding protein-likesearch Lipocalinsearch PF00061: Lipocalin / cytosolic fatty-acid binding protein familysearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P11589) transporter activitysearch pheromone bindingsearch insulin-activated receptor activitysearch small molecule bindingsearch positive regulation of gene expressionsearch heat generationsearch positive regulation of lipid metabolic processsearch cellular response to lipidsearch mitochondrion morphogenesissearch negative regulation of gluconeogenesissearch transportsearch negative regulation of lipid storagesearch locomotor rhythmsearch positive regulation of glucose metabolic processsearch glucose homeostasissearch positive regulation of protein kinase B signalingsearch insulin receptor signaling pathwaysearch negative regulation of transcription, DNA-templatedsearch negative regulation of lipid biosynthetic processsearch negative regulation of insulin secretion involved in cellular response to glucose stimulussearch energy reserve metabolic processsearch aerobic respirationsearch nucleussearch extracellular regionsearch cytosolsearch extracellular spacesearch

Chain InterPro annotation
A Lipocalin/cytosolic fatty-acid binding domainsearch Lipocalinsearch Major urinary proteinsearch Calycin-likesearch Calycinsearch Lipocalin family conserved sitesearch