1zmw Summary

pdbe.org/1zmw
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Catalytic and ubiqutin-associated domains of MARK2/PAR-1: T208A/S212A inactive double mutant

The structure was published by Panneerselvam, S., Marx, A., Mandelkow, E.M., and Mandelkow, E., in 2006 in a paper entitled "Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.802 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of MAP/Microtubule affinity regulating kinase 2.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MAP/Microtubule affinity regulating kinase 2 O08679 (39-364) (MARK2_RAT)search Rattus norvegicussearch < 90% 327 92%
B MAP/Microtubule affinity regulating kinase 2 O08679 (39-364) (MARK2_RAT)search Rattus norvegicussearch < 90% 327 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O08679 (39 - 364) MAP/Microtubule affinity regulating kinase 2 Rattus norvegicus

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Transferase(Phosphotransferase) domain 1search, DNA helicase RuvA subunit, C-terminal domainsearch Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (O08679) ATP bindingsearch protein serine/threonine kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryotesearch Protein kinase, ATP binding sitesearch