1zme Summary

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CRYSTAL STRUCTURE OF PUT3/DNA COMPLEX

The structure was published by Swaminathan, K., Flynn, P., Reece, R.J., and Marmorstein, R., in 1997 in a paper entitled "Crystal structure of a PUT3-DNA complex reveals a novel mechanism for DNA recognition by a protein containing a Zn2Cys6 binuclear cluster." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1997.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely DNA (5'-D(*AP*CP*GP*GP*GP*AP*AP*GP*CP*CP*AP*AP*CP*TP*CP*CP*G)-3'), DNA (5'-D(*AP*CP*GP*GP*AP*GP*(5IU)P*TP*GP*GP*CP*TP*(5IU)P*CP*CP*CP*G)-3'), and PROLINE UTILIZATION TRANSCRIPTION ACTIVATOR.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
C PROLINE UTILIZATION TRANSCRIPTION ACTIVATOR P25502 (31-100) (PUT3_YEAST)search Saccharomyces cerevisiae S288csearch < 90% 70 100%
D PROLINE UTILIZATION TRANSCRIPTION ACTIVATOR P25502 (31-100) (PUT3_YEAST)search Saccharomyces cerevisiae S288csearch < 90% 70 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P25502 (31 - 100) PROLINE UTILIZATION TRANSCRIPTION ACTIVATOR Saccharomyces cerevisiae

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
C, D Zn2/Cys6 DNA-binding domainsearch, Leucine zipper domainsearch CD2-Gal4search Fungal Zn(2)-Cys(6) binuclear cluster domainsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
C, D (P25502) nucleussearch zinc ion bindingsearch sequence-specific DNA binding RNA polymerase II transcription factor activitysearch regulation of transcription, DNA-templatedsearch

Chain InterPro annotation
C, D Zn(2)-C6 fungal-type DNA-binding domainsearch