1zlt Summary

pdbe.org/1zlt
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Crystal Structure of Chk1 Complexed with a Hymenaldisine Analog

A publication describing this structure is not available. The depositing authors are Lee, C.C.search; Ng, K.search; Wan, Y.search; Gray, N.search; Spraggon, G.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.74 Å and deposited in 2005.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Serine/threonine-protein kinase Chk1. This molecule has the UniProt identifier O14757 (CHK1_HUMAN)search. The sample contained 295 residues which is < 90% of the natural sequence. Out of 295 residues 272 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Serine/threonine-protein kinase Chk1 O14757 (1-289) (CHK1_HUMAN)search Homo sapienssearch < 90% 295 92%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O14757 (1 - 289) Serine/threonine-protein kinase Chk1 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A (O14757) protein phosphorylationsearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein serine/threonine kinase activitysearch protein kinase activitysearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch