1zky Summary

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Human Estrogen Receptor Alpha Ligand-Binding Domain In Complex With OBCP-3M and A Glucocorticoid Receptor Interacting Protein 1 Nr Box II Peptide

The structure was published by Hsieh, R.W., Rajan, S.S., Sharma, S.K., et al., Desombre, E.R., Mrksich, M., and Greene, G.L., in 2006 in a paper entitled "Identification of ligands with bicyclic scaffolds provides insights into mechanisms of estrogen receptor subtype selectivity." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.25 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Estrogen receptor and Nuclear receptor coactivator 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Estrogen receptor P03372 (298-554) (ESR1_HUMAN)search Homo sapienssearch < 90% 257 95%
B Estrogen receptor P03372 (298-554) (ESR1_HUMAN)search Homo sapienssearch < 90% 257 95%
C Nuclear receptor coactivator 2 Q15596 (686-698) (NCOA2_HUMAN)search Homo sapienssearch < 90% 13 76%
D Nuclear receptor coactivator 2 Q15596 (686-698) (NCOA2_HUMAN)search Homo sapienssearch < 90% 13 76%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P03372 (298 - 554) Estrogen receptor Homo sapiens
Q15596 (686 - 698) Nuclear receptor coactivator 2

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch, Oestrogen-type nuclear receptor final C-terminalsearch
C, D Steroid receptor coactivatorsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P03372) sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch DNA bindingsearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
C, D Nuclear receptor coactivator Src-1search