1zjd Summary

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Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with Kunitz Protease Inhibitor Domain of Protease Nexin II

The structure was published by Navaneetham, D., Jin, L., Pandey, P., et al., Babine, R.E., Abdel-Meguid, S.S., and Walsh, P.N., in 2005 in a paper entitled "Structural and Mutational Analyses of the Molecular Interactions between the Catalytic Domain of Factor XIa and the Kunitz Protease Inhibitor Domain of Protease Nexin 2" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Catalytic Domain of Coagulation Factor XI and Kunitz Protease Inhibitory Domain of Protease Nexin II.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Catalytic Domain of Coagulation Factor XI P03951 (388-624) (FA11_HUMAN)search Homo sapienssearch < 90% 237 100%
B Kunitz Protease Inhibitory Domain of Protease Nexin II P05067 (289-344) (A4_HUMAN)search Homo sapienssearch < 90% 57 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P03951 (388 - 624) Catalytic Domain of Coagulation Factor XI Homo sapiens
P05067 (289 - 344) Kunitz Protease Inhibitory Domain of Protease Nexin II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P03951) Eukaryotic proteasessearch Trypsin-like serine proteasessearch PF00089: Trypsinsearch
B Small Kunitz-type inhibitors & BPTI-like toxinssearch Factor Xa Inhibitorsearch Kunitz/Bovine pancreatic trypsin inhibitor domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (P03951) catalytic activitysearch serine-type endopeptidase activitysearch proteolysissearch
B (P05067) serine-type endopeptidase inhibitor activitysearch

Chain InterPro annotation
A Peptidase S1search Peptidase S1A, chymotrypsin-typesearch Trypsin-like cysteine/serine peptidase domainsearch Peptidase S1, trypsin family, active sitesearch
B Proteinase inhibitor I2, Kunitz metazoasearch Proteinase inhibitor I2, Kunitz, conserved sitesearch