› 1zj6

X-ray diffraction
2Å resolution

Crystal structure of human ARL5

Released:
DOI: 10.2210/pdb1zj6/pdb
PDB entry 1zj6 coloured by chain, front view.
PDB entry 1zj6 coloured by chain, side view.
PDB entry 1zj6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
2.0 A crystal structure of human ARL5-GDP3'P, a novel member of the small GTP-binding proteins.
Wang ZX, Shi L, Liu JF, An XM, Chang WR, Liang DC
Biochem Biophys Res Commun 332 640-5 (2005)
PMID: 15896705

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-195342 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ADP-ribosylation factor-like protein 5A Chain: A
Molecule details ›
Chain: A
Length: 187 amino acids
Theoretical weight: 21.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y689 (Residues: 1-179; Coverage: 100%)
Gene names: ARFLP5, ARL5, ARL5A
Sequence domains: ADP-ribosylation factor family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand SO4 2 x SO4
Ligand G3D 1 x G3D
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-6B
Spacegroup: I212121
Unit cell:
a: 76.78Å b: 81.46Å c: 84.61Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.212 0.223
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Structure-function relationships of the G domain, a canonical switch motif.
Wittinghofer et al. (2011)
2 other articles

1 mention without citation

A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region.
Schroeder et al. (2014)