1zh7 Summary

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Structural and Biochemical Basis for Selective Repression of the Orphan Nuclear Receptor LRH-1 by SHP

The structure was published by Li, Y., Choi, M., Suino, K., et al., Daugherty, J., Kliewer, S.A., and Xu, H.E., in 2005 in a paper entitled "Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Orphan nuclear receptor NR5A2 and nuclear receptor subfamily 0, group B, member 2.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Orphan nuclear receptor NR5A2 P45448 (318-560) (NR5A2_MOUSE)search Mus musculussearch < 90% 243 100%
B Orphan nuclear receptor NR5A2 P45448 (318-560) (NR5A2_MOUSE)search Mus musculussearch < 90% 243 100%
C nuclear receptor subfamily 0, group B, member 2 P97947 (16-26) (NR0B2_RAT)search Rattus norvegicussearch < 90% 11 100%
D nuclear receptor subfamily 0, group B, member 2 P97947 (16-26) (NR0B2_RAT)search Rattus norvegicussearch < 90% 11 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P45448 (318 - 560) Orphan nuclear receptor NR5A2 Mus musculus
P97947 (16 - 26) nuclear receptor subfamily 0, group B, member 2 Rattus norvegicus

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
C, D

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P45448) steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch nucleussearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
C, D