1zgy Summary

pdbe.org/1zgy
spacer

Structural and Biochemical Basis for Selective Repression of the Orphan Nuclear Receptor LRH-1 by SHP

The structure was published by Li, Y., Choi, M., Suino, K., et al., Daugherty, J., Kliewer, S.A., and Xu, H.E., in 2005 in a paper entitled "Structural and biochemical basis for selective repression of the orphan nuclear receptor liver receptor homolog 1 by small heterodimer partner." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Peroxisome proliferator activated receptor gamma and Nuclear receptor subfamily 0, group B, member 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Peroxisome proliferator activated receptor gamma P37231 (234-505) (PPARG_HUMAN)search Homo sapienssearch < 90% 272 100%
B Nuclear receptor subfamily 0, group B, member 2 P97947 (115-131) (NR0B2_RAT)search Rattus norvegicussearch < 90% 17 70%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P37231 (234 - 505) Peroxisome proliferator activated receptor gamma Homo sapiens
P97947 (115 - 131) Nuclear receptor subfamily 0, group B, member 2 Rattus norvegicus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
B Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P37231) sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch DNA bindingsearch ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitysearch regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch nucleussearch

Chain InterPro annotation
A Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Peroxisome proliferator-activated receptorsearch Nuclear hormone receptor, ligand-bindingsearch
B