1zgn Summary


Crystal Structure of the Glutathione Transferase Pi in Complex with Dinitrosyl-diglutathionyl Iron Complex

The structure was published by Cesareo, E., Parker, L.J., Pedersen, J.Z., et al., Adams, J.J., Parker, M.W., and Bello, M.L., in 2005 in a paper entitled "Nitrosylation of human glutathione transferase P1-1 with dinitrosyl diglutathionyl iron complex in vitro and in vivo" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glutathione S-transferase P.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glutathione S-transferase P P09211 (2-210) (GSTP1_HUMAN)search Homo sapienssearch 96% 209 99%
B Glutathione S-transferase P P09211 (2-210) (GSTP1_HUMAN)search Homo sapienssearch 96% 209 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P09211 (2 - 210) Glutathione S-transferase P Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P09211) Glutathione S-transferase (GST), C-terminal domainsearch, Glutathione S-transferase (GST), N-terminal domainsearch Glutaredoxinsearch, Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2search PF00043: Glutathione S-transferase, C-terminal domainsearch, PF02798: Glutathione S-transferase, N-terminal domainsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B (P09211) xenobiotic metabolic processsearch glutathione metabolic processsearch central nervous system developmentsearch glutathione derivative biosynthetic processsearch negative regulation of tumor necrosis factor productionsearch regulation of ERK1 and ERK2 cascadesearch negative regulation of stress-activated MAPK cascadesearch negative regulation of ERK1 and ERK2 cascadesearch negative regulation of interleukin-1 beta productionsearch negative regulation of JUN kinase activitysearch regulation of stress-activated MAPK cascadesearch nitric oxide storagesearch negative regulation of acute inflammatory responsesearch negative regulation of fibroblast proliferationsearch negative regulation of tumor necrosis factor-mediated signaling pathwaysearch negative regulation of biosynthetic processsearch common myeloid progenitor cell proliferationsearch positive regulation of superoxide anion generationsearch negative regulation of MAPK cascadesearch negative regulation of I-kappaB kinase/NF-kappaB signalingsearch negative regulation of monocyte chemotactic protein-1 productionsearch metabolic processsearch small molecule metabolic processsearch negative regulation of protein kinase activitysearch response to reactive oxygen speciessearch cellular response to lipopolysaccharidesearch negative regulation of MAP kinase activitysearch negative regulation of apoptotic processsearch negative regulation of extrinsic apoptotic signaling pathwaysearch negative regulation of leukocyte proliferationsearch negative regulation of nitric-oxide synthase biosynthetic processsearch cytosolsearch cytoplasmsearch plasma membranesearch mitochondrionsearch nucleussearch extracellular vesicular exosomesearch TRAF2-GSTP1 complexsearch vesiclesearch extracellular spacesearch intracellularsearch nitric oxide bindingsearch dinitrosyl-iron complex bindingsearch kinase regulator activitysearch glutathione transferase activitysearch protein bindingsearch S-nitrosoglutathione bindingsearch JUN kinase bindingsearch transferase activitysearch

Chain InterPro annotation
A, B Glutathione S-transferase, Pi classsearch Glutathione S-transferase, N-terminalsearch Glutathione S-transferase, C-terminalsearch Glutathione S-transferase, C-terminal-likesearch Thioredoxin-like foldsearch