1zgf Summary


carbonic anhydrase II in complex with trichloromethiazide as sulfonamide inhibitor

A publication describing this structure is not available. The depositing authors are Honndorf, V.S.search; Heine, A.search; Klebe, G.search; Supuran, C.T.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.75 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 99% of the natural sequence. Out of 259 residues 255 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase II P00918 (2-259) (CAH2_HUMAN)search Homo sapienssearch 98% 259 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 259) Carbonic anhydrase II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P00918) cytoplasmsearch plasma membranesearch cytosolsearch membranesearch extracellular vesicular exosomesearch extracellular spacesearch apical part of cellsearch axonsearch microvillussearch myelin sheathsearch basolateral plasma membranesearch regulation of chloride transportsearch bicarbonate transportsearch angiotensin-activated signaling pathwaysearch response to steroid hormonesearch kidney developmentsearch odontogenesis of dentin-containing toothsearch positive regulation of cellular pH reductionsearch response to organic substancesearch one-carbon metabolic processsearch positive regulation of dipeptide transmembrane transportsearch morphogenesis of an epitheliumsearch response to pHsearch regulation of intracellular pHsearch small molecule metabolic processsearch response to estrogensearch regulation of anion transportsearch positive regulation of bone resorptionsearch secretionsearch cellular response to fluid shear stresssearch response to zinc ionsearch positive regulation of synaptic transmission, GABAergicsearch positive regulation of osteoclast differentiationsearch lyase activitysearch carbonate dehydratase activitysearch protein bindingsearch zinc ion bindingsearch metal ion bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch