1zge Summary


carbonic anhydrase II in complex with p-Sulfonamido-o,o'-dichloroaniline as sulfonamide inhibitor

A publication describing this structure is not available. The depositing authors are Honndorf, V.S.search; Heine, A.search; Klebe, G.search; Supuran, C.T.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.65 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase II. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 99% of the natural sequence. Out of 259 residues 253 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase II P00918 (2-259) (CAH2_HUMAN)search Homo sapienssearch 98% 259 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 259) Carbonic anhydrase II Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic anhydrasesearch Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P00918) cytoplasmsearch basolateral plasma membranesearch myelin sheathsearch membranesearch cytosolsearch extracellular vesicular exosomesearch apical part of cellsearch plasma membranesearch axonsearch extracellular spacesearch microvillussearch regulation of intracellular pHsearch positive regulation of cellular pH reductionsearch regulation of anion transportsearch one-carbon metabolic processsearch response to organic substancesearch bicarbonate transportsearch response to pHsearch positive regulation of dipeptide transmembrane transportsearch positive regulation of bone resorptionsearch positive regulation of synaptic transmission, GABAergicsearch response to steroid hormonesearch positive regulation of osteoclast differentiationsearch response to estrogensearch response to zinc ionsearch odontogenesis of dentin-containing toothsearch small molecule metabolic processsearch morphogenesis of an epitheliumsearch regulation of chloride transportsearch angiotensin-activated signaling pathwaysearch kidney developmentsearch secretionsearch protein bindingsearch carbonate dehydratase activitysearch zinc ion bindingsearch lyase activitysearch metal ion bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch