1zfs Summary

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Solution structure of S100A1 bound to calcium

The structure was published by Wright, N.T., Varney, K.M., Ellis, K.C., et al., Gitti, R.K., Zimmer, D.B., and Weber, D.J., in 2006 in a paper entitled "The three-dimensional solution structure of Ca(2+)-bound S100A1 as determined by NMR spectroscopy" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of S-100 protein, alpha chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A S-100 protein, alpha chain P35467 (2-94) (S10A1_RAT)search Rattus norvegicussearch 99% 93 100%
B S-100 protein, alpha chain P35467 (2-94) (S10A1_RAT)search Rattus norvegicussearch 99% 93 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35467 (2 - 94) S-100 protein, alpha chain Rattus norvegicus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P35467) S100 proteinssearch EF-handsearch PF00036: EF handsearch, PF01023: S-100/ICaBP type calcium binding domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P35467) calcium ion bindingsearch protein homodimerization activitysearch protein bindingsearch metal ion bindingsearch S100 protein bindingsearch calcium-dependent protein bindingsearch identical protein bindingsearch ATPase bindingsearch A bandsearch M bandsearch Z discsearch I bandsearch cytoplasmsearch sarcoplasmic reticulumsearch cytosolsearch neuron projectionsearch nucleussearch negative regulation of transcription from RNA polymerase II promotersearch regulation of heart contractionsearch substantia nigra developmentsearch positive regulation of voltage-gated calcium channel activitysearch

Chain InterPro annotation
A, B S100/Calbindin-D9k, conserved sitesearch EF-hand domainsearch EF-hand domain pairsearch S100/CaBP-9k-type, calcium binding, subdomainsearch EF-Hand 1, calcium-binding sitesearch Protein S100-A1search