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Solution NMR

Solution structure of S100A1 bound to calcium

Released:
DOI: 10.2210/pdb1zfs/pdb
PDB entry 1zfs coloured by chain, ensemble of 19 models, front view.
PDB entry 1zfs coloured by chain, ensemble of 19 models, side view.
PDB entry 1zfs coloured by chain, ensemble of 19 models, top view.
Source organism: Rattus norvegicus
Primary publication:
The three-dimensional solution structure of Ca(2+)-bound S100A1 as determined by NMR spectroscopy.
Wright NT, Varney KM, Ellis KC, Markowitz J, Gitti RK, Zimmer DB, Weber DJ
J Mol Biol 353 410-26 (2005)
PMID: 16169012

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152927 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein S100-A1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 93 amino acids
Theoretical weight: 10.44 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P35467 (Residues: 2-94; Coverage: 99%)
Gene name: S100a1
Sequence domains:
Structure domains: EF-hand

Ligands and Environments

1 bound ligand:
Ligand CA 4 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry simulated annealing (DGSA)
Expression system: Escherichia coli

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Citations

14 review citations

S100A4 calcium-binding protein is key player in tumor progression and metastasis: preclinical and clinical evidence.
Mishra et al. (2012)
13 more

11 mentions without citation

S100A1 and calmodulin compete for the same binding site on ryanodine receptor.
Wright et al. (2008)
10 more