1zeo Summary


Crystal Structure of Human PPAR-gamma Ligand Binding Domain Complexed with an Alpha-Aryloxyphenylacetic Acid Agonist

The structure was published by Shi, G.Q., Dropinski, J.F., McKeever, B.M., et al., Heck, J.V., Moller, D.E., and Jones, B.A., in 2005 in a paper entitled "Design and Synthesis of alpha-Aryloxyphenylacetic Acid Derivatives: A Novel Class of PPAR alpha/gamma Dual Agonists with Potent Antihyperglycemic and Lipid Modulating Activity" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Peroxisome proliferator activated receptor gamma.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Peroxisome proliferator activated receptor gamma P37231 (231-505) (PPARG_HUMAN)search Homo sapienssearch < 90% 277 94%
B Peroxisome proliferator activated receptor gamma P37231 (231-505) (PPARG_HUMAN)search Homo sapienssearch < 90% 277 94%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P37231 (231 - 505) Peroxisome proliferator activated receptor gamma Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B (P37231) regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch nucleussearch DNA bindingsearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activitysearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Peroxisome proliferator-activated receptorsearch Nuclear hormone receptor, ligand-bindingsearch