› 1zdt

X-ray diffraction
2.1Å resolution

The Crystal Structure of Human Steroidogenic Factor-1

Released:
DOI: 10.2210/pdb1zdt/pdb
PDB entry 1zdt coloured by chain, front view.
PDB entry 1zdt coloured by chain, side view.
PDB entry 1zdt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1.
Wang W, Zhang C, Marimuthu A, Krupka HI, Tabrizizad M, Shelloe R, Mehra U, Eng K, Nguyen H, Settachatgul C, Powell B, Milburn MV, West BL
Proc Natl Acad Sci U S A 102 7505-10 (2005)
PMID: 15897460

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-171629 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Steroidogenic factor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 241 amino acids
Theoretical weight: 27.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13285 (Residues: 221-461; Coverage: 52%)
Gene names: AD4BP, FTZF1, NR5A1, SF1
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 2 Chains: P, Q
Molecule details ›
Chains: P, Q
Length: 12 amino acids
Theoretical weight: 1.46 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 741-752; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2

Ligands and Environments

1 bound ligand:
Ligand PEF 2 x PEF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P3121
Unit cell:
a: 73.601Å b: 73.601Å c: 195.678Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.218 0.216 0.265
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

25 review citations

Estrogen signaling through the transmembrane G protein-coupled receptor GPR30.
Prossnitz et al. (2008)
24 more

9 mentions without citation

Wide spectrum of NR5A1-related phenotypes in 46,XY and 46,XX individuals.
Domenice et al. (2016)
8 more