1zdt Summary

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The Crystal Structure of Human Steroidogenic Factor-1

The structure was published by Wang, W., Zhang, C., Marimuthu, A., et al., Powell, B., Milburn, M.V., and West, B.L., in 2005 in a paper entitled "The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Steroidogenic factor 1 and Nuclear receptor coactivator 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Steroidogenic factor 1 Q13285 (221-461) (STF1_HUMAN)search Homo sapienssearch < 90% 241 99%
B Steroidogenic factor 1 Q13285 (221-461) (STF1_HUMAN)search Homo sapienssearch < 90% 241 99%
P Nuclear receptor coactivator 2 Q15596 (741-752) (NCOA2_HUMAN)search Homo sapienssearch < 90% 12 100%
Q Nuclear receptor coactivator 2 Q15596 (741-752) (NCOA2_HUMAN)search Homo sapienssearch < 90% 12 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q13285 (221 - 461) Steroidogenic factor 1 Homo sapiens
Q15596 (741 - 752) Nuclear receptor coactivator 2

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
P, Q

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, B (Q13285) nucleussearch steroid hormone receptor activitysearch sequence-specific DNA binding transcription factor activitysearch DNA bindingsearch steroid hormone mediated signaling pathwaysearch regulation of transcription, DNA-templatedsearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
P, Q