1zcl Summary

pdbe.org/1zcl
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prl-1 c104s mutant in complex with sulfate

The structure was published by Sun, J.P., Wang, W.Q., Yang, H., et al., Fedorov, A.A., Almo, S.C., and Zhang, Z.Y., in 2005 in a paper entitled "Structure and Biochemical Properties of PRL-1, a Phosphatase Implicated in Cell Growth, Differentiation, and Tumor Invasion." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of protein tyrosine phosphatase 4a1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A protein tyrosine phosphatase 4a1 Q78EG7 (1-160) (TP4A1_RAT)search Rattus norvegicussearch 92% 180 84%
B protein tyrosine phosphatase 4a1 Q78EG7 (1-160) (TP4A1_RAT)search Rattus norvegicussearch 92% 180 84%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q78EG7 (1 - 160) protein tyrosine phosphatase 4a1 Rattus norvegicus

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (Q78EG7) Protein tyrosine phosphatase superfamilysearch PF00782: Dual specificity phosphatase, catalytic domainsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A, B (Q78EG7) nucleussearch membranesearch cytoplasmsearch spindlesearch cytoskeletonsearch endosomesearch endoplasmic reticulumsearch plasma membranesearch early endosomesearch extracellular vesicular exosomesearch cytoplasmic side of plasma membranesearch phosphatase activitysearch protein tyrosine/serine/threonine phosphatase activitysearch protein tyrosine phosphatase activitysearch phosphoprotein phosphatase activitysearch hydrolase activitysearch protein dephosphorylationsearch dephosphorylationsearch positive regulation of cell migrationsearch peptidyl-tyrosine dephosphorylationsearch cell cyclesearch multicellular organismal developmentsearch

Chain InterPro annotation
A, B Dual specificity phosphatase, catalytic domainsearch Protein-tyrosine/Dual specificity phosphatasesearch Protein-tyrosine phosphatase-likesearch