1z9h Summary

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Microsomal prostaglandin E synthase type-2

The structure was published by Yamada, T., Komoto, J., Watanabe, K., Ohmiya, Y., and Takusagawa, F., in 2005 in a paper entitled "Crystal Structure and Possible Catalytic Mechanism of Microsomal Prostaglandin E Synthase Type 2 (mPGES-2)." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of membrane-associated prostaglandin E synthase-2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A membrane-associated prostaglandin E synthase-2 Q9N0A4 (88-377) (PGES2_MACFA)search Macaca fascicularissearch < 90% 290 94%
B membrane-associated prostaglandin E synthase-2 Q9N0A4 (88-377) (PGES2_MACFA)search Macaca fascicularissearch < 90% 290 94%
C membrane-associated prostaglandin E synthase-2 Q9N0A4 (88-377) (PGES2_MACFA)search Macaca fascicularissearch < 90% 290 94%
D membrane-associated prostaglandin E synthase-2 Q9N0A4 (88-377) (PGES2_MACFA)search Macaca fascicularissearch < 90% 290 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9N0A4 (88 - 377) membrane-associated prostaglandin E synthase-2 Macaca fascicularis

Chain Structural classification (SCOP) Sequence family (Pfam)
A, B, C, D Glutathione S-transferase (GST), C-terminal domainsearch, Glutathione S-transferase (GST), N-terminal domainsearch Glutaredoxinsearch, Glutathione S-transferase, C-terminal domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A, B, C, D (Q9N0A4) cell redox homeostasissearch protein disulfide oxidoreductase activitysearch electron carrier activitysearch

Chain InterPro annotation
A, B, C, D Glutaredoxinsearch Glutathione S-transferase, N-terminalsearch Glutathione S-transferase, C-terminalsearch Glutathione S-transferase, C-terminal-likesearch Glutaredoxin active sitesearch Thioredoxin-like foldsearch