1z92 Summary

pdbe.org/1z92
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structure of interleukin-2 with its alpha receptor

The structure was published by Rickert, M., Wang, X., Boulanger, M.J., Goriatcheva, N., and Garcia, K.C., in 2005 in a paper entitled "The structure of interleukin-2 complexed with its alpha receptor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Interleukin-2 and Interleukin-2 receptor alpha chain.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Interleukin-2 P60568 (21-153) (IL2_HUMAN)search Homo sapienssearch 99% 133 90%
B Interleukin-2 receptor alpha chain P01589 (22-238) (IL2RA_HUMAN)search Homo sapienssearch < 90% 219 56%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P60568 (21 - 153) Interleukin-2 Homo sapiens
P01589 (22 - 238) Interleukin-2 receptor alpha chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P60568) Short-chain cytokinessearch Growth Hormone; Chain: A;search PF00715: Interleukin 2search
B Complement control module/SCR domainsearch Complement Module, domain 1search Sushi domain (SCR repeat)search

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P60568) interleukin-2 receptor bindingsearch growth factor activitysearch glycosphingolipid bindingsearch cytokine activitysearch carbohydrate bindingsearch kappa-type opioid receptor bindingsearch kinase activator activitysearch immune responsesearch positive regulation of B cell proliferationsearch positive regulation of isotype switching to IgG isotypessearch immune system processsearch negative regulation of apoptotic processsearch positive regulation of tissue remodelingsearch positive regulation of T cell proliferationsearch positive regulation of activated T cell proliferationsearch negative regulation of inflammatory responsesearch positive regulation of interferon-gamma productionsearch positive regulation of tyrosine phosphorylation of Stat5 proteinsearch negative regulation of B cell apoptotic processsearch positive regulation of T cell differentiationsearch cell-cell signalingsearch positive regulation of cell growthsearch positive regulation of interleukin-17 productionsearch positive regulation of transcription from RNA polymerase II promotersearch positive regulation of cytosolic calcium ion concentrationsearch negative regulation of heart contractionsearch T cell differentiationsearch G-protein coupled receptor signaling pathwaysearch negative regulation of protein phosphorylationsearch positive regulation of immunoglobulin secretionsearch positive regulation of cell proliferationsearch positive regulation of protein phosphorylationsearch regulation of T cell homeostatic proliferationsearch negative regulation of lymphocyte proliferationsearch positive regulation of regulatory T cell differentiationsearch positive regulation of dendritic spine developmentsearch natural killer cell activationsearch cell adhesionsearch positive regulation of inflammatory responsesearch extrinsic apoptotic signaling pathway in absence of ligandsearch protein kinase C-activating G-protein coupled receptor signaling pathwaysearch extracellular regionsearch extracellular spacesearch

Chain InterPro annotation
A Interleukin-2search Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch
B Sushi/SCR/CCPsearch Interleukin-2 receptor alphasearch