1z92 Summary


structure of interleukin-2 with its alpha receptor

The structure was published by Rickert, M., Wang, X., Boulanger, M.J., Goriatcheva, N., and Garcia, K.C., in 2005 in a paper entitled "The structure of interleukin-2 complexed with its alpha receptor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Interleukin-2 and Interleukin-2 receptor alpha chain.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Interleukin-2 P60568 (21-153) (IL2_HUMAN)search Homo sapienssearch 99% 133 90%
B Interleukin-2 receptor alpha chain P01589 (22-238) (IL2RA_HUMAN)search Homo sapienssearch < 90% 219 56%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P60568 (21 - 153) Interleukin-2 Homo sapiens
P01589 (22 - 238) Interleukin-2 receptor alpha chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P60568) Short-chain cytokinessearch Growth Hormone; Chain: A;search PF00715: Interleukin 2search
B Complement control module/SCR domainsearch Sushi domain (SCR repeat)search

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P60568) growth factor activitysearch cytokine activitysearch interleukin-2 receptor bindingsearch carbohydrate bindingsearch glycosphingolipid bindingsearch kappa-type opioid receptor bindingsearch kinase activator activitysearch immune responsesearch positive regulation of T cell proliferationsearch G-protein coupled receptor signaling pathwaysearch negative regulation of apoptotic processsearch positive regulation of regulatory T cell differentiationsearch positive regulation of B cell proliferationsearch immune system processsearch positive regulation of activated T cell proliferationsearch positive regulation of tissue remodelingsearch negative regulation of protein phosphorylationsearch positive regulation of isotype switching to IgG isotypessearch negative regulation of B cell apoptotic processsearch T cell differentiationsearch positive regulation of dendritic spine developmentsearch extrinsic apoptotic signaling pathway in absence of ligandsearch positive regulation of tyrosine phosphorylation of Stat5 proteinsearch positive regulation of transcription from RNA polymerase II promotersearch negative regulation of lymphocyte proliferationsearch cell-cell signalingsearch positive regulation of cell growthsearch positive regulation of interleukin-17 productionsearch positive regulation of protein phosphorylationsearch negative regulation of inflammatory responsesearch natural killer cell activationsearch positive regulation of cytosolic calcium ion concentrationsearch negative regulation of heart contractionsearch positive regulation of cell proliferationsearch protein kinase C-activating G-protein coupled receptor signaling pathwaysearch positive regulation of immunoglobulin secretionsearch regulation of T cell homeostatic proliferationsearch positive regulation of T cell differentiationsearch cell adhesionsearch positive regulation of inflammatory responsesearch positive regulation of interferon-gamma productionsearch extracellular regionsearch extracellular spacesearch

Chain InterPro annotation
A Interleukin-2search Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch
B Sushi/SCR/CCPsearch Interleukin-2 receptor alphasearch