1z92 Summary


structure of interleukin-2 with its alpha receptor

The structure was published by Rickert, M., Wang, X., Boulanger, M.J., Goriatcheva, N., and Garcia, K.C., in 2005 in a paper entitled "The structure of interleukin-2 complexed with its alpha receptor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Interleukin-2 and Interleukin-2 receptor alpha chain.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Interleukin-2 P60568 (21-153) (IL2_HUMAN)search Homo sapienssearch 98% 133 90%
B Interleukin-2 receptor alpha chain P01589 (22-238) (IL2RA_HUMAN)search Homo sapienssearch < 90% 219 56%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P60568 (21 - 153) Interleukin-2 Homo sapiens
P01589 (22 - 238) Interleukin-2 receptor alpha chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P60568) Short-chain cytokinessearch Growth Hormone; Chain: A;search PF00715: Interleukin 2search
B Complement control module/SCR domainsearch Complement Module, domain 1search Sushi domain (SCR repeat)search

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P60568) interleukin-2 receptor bindingsearch growth factor activitysearch carbohydrate bindingsearch cytokine activitysearch kappa-type opioid receptor bindingsearch glycosphingolipid bindingsearch kinase activator activitysearch positive regulation of dendritic spine developmentsearch positive regulation of T cell proliferationsearch positive regulation of B cell proliferationsearch regulation of T cell homeostatic proliferationsearch negative regulation of apoptotic processsearch positive regulation of cytosolic calcium ion concentrationsearch positive regulation of activated T cell proliferationsearch positive regulation of tissue remodelingsearch negative regulation of heart contractionsearch T cell differentiationsearch positive regulation of interferon-gamma productionsearch cell-cell signalingsearch positive regulation of cell growthsearch positive regulation of interleukin-17 productionsearch positive regulation of regulatory T cell differentiationsearch positive regulation of immunoglobulin secretionsearch negative regulation of B cell apoptotic processsearch negative regulation of lymphocyte proliferationsearch positive regulation of T cell differentiationsearch positive regulation of tyrosine phosphorylation of Stat5 proteinsearch protein kinase C-activating G-protein coupled receptor signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch negative regulation of inflammatory responsesearch immune system processsearch positive regulation of cell proliferationsearch positive regulation of isotype switching to IgG isotypessearch natural killer cell activationsearch negative regulation of protein phosphorylationsearch extrinsic apoptotic signaling pathway in absence of ligandsearch positive regulation of protein phosphorylationsearch G-protein coupled receptor signaling pathwaysearch immune responsesearch cell adhesionsearch positive regulation of inflammatory responsesearch extracellular regionsearch extracellular spacesearch

Chain InterPro annotation
A Interleukin-2search Four-helical cytokine-like, coresearch Four-helical cytokine, coresearch
B Sushi/SCR/CCP domainsearch Interleukin-2 receptor alphasearch