1z8u Summary

pdbe.org/1z8u
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Crystal structure of oxidized alpha hemoglobin bound to AHSP

The structure was published by Feng, L., Zhou, S., Gu, L., et al., Weiss, M.J., Gow, A.J., and Shi, Y., in 2005 in a paper entitled "Structure of oxidized alpha-haemoglobin bound to AHSP reveals a protective mechanism for haem." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2005.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Alpha-hemoglobin stabilizing protein and Hemoglobin alpha chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Alpha-hemoglobin stabilizing protein Q9NZD4 (1-102) (AHSP_HUMAN)search Homo sapienssearch 90% 102 89%
C Alpha-hemoglobin stabilizing protein Q9NZD4 (1-102) (AHSP_HUMAN)search Homo sapienssearch 90% 102 89%
B Hemoglobin alpha chain P69905 (1-142) (HBA_HUMAN)search Homo sapienssearch 98% 142 95%
D Hemoglobin alpha chain P69905 (1-142) (HBA_HUMAN)search Homo sapienssearch 98% 142 95%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q9NZD4 (1 - 102) Alpha-hemoglobin stabilizing protein Homo sapiens
P69905 (1 - 142) Hemoglobin alpha chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (Q9NZD4) Alpha-hemoglobin stabilizing protein AHSPsearch Alpha-hemoglobin stabilizing proteinsearch PF09236: Alpha-haemoglobin stabilising proteinsearch
B, D (P69905) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, C (Q9NZD4) hemoglobin complexsearch cytoplasmsearch hemopoiesissearch protein stabilizationsearch hemoglobin metabolic processsearch protein foldingsearch unfolded protein bindingsearch hemoglobin bindingsearch
B, D (P69905) haptoglobin-hemoglobin complexsearch extracellular regionsearch hemoglobin complexsearch extracellular vesicular exosomesearch cytosolsearch blood microparticlesearch endocytic vesicle lumensearch cytosolic small ribosomal subunitsearch membranesearch positive regulation of cell deathsearch receptor-mediated endocytosissearch small molecule metabolic processsearch bicarbonate transportsearch oxygen transportsearch oxidation-reduction processsearch transportsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch response to hydrogen peroxidesearch heme bindingsearch iron ion bindingsearch protein bindingsearch oxygen transporter activitysearch metal ion bindingsearch haptoglobin bindingsearch oxygen bindingsearch peroxidase activitysearch

Chain InterPro annotation
A, C Alpha-haemoglobin stabilising proteinsearch
B, D Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch