1z8u Summary

pdbe.org/1z8u
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Crystal structure of oxidized alpha hemoglobin bound to AHSP

The structure was published by Feng, L., Zhou, S., Gu, L., et al., Weiss, M.J., Gow, A.J., and Shi, Y., in 2005 in a paper entitled "Structure of oxidized alpha-haemoglobin bound to AHSP reveals a protective mechanism for haem." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2005.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Alpha-hemoglobin stabilizing protein and Hemoglobin alpha chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Alpha-hemoglobin stabilizing protein Q9NZD4 (1-102) (AHSP_HUMAN)search Homo sapienssearch 90% 102 89%
C Alpha-hemoglobin stabilizing protein Q9NZD4 (1-102) (AHSP_HUMAN)search Homo sapienssearch 90% 102 89%
B Hemoglobin alpha chain P69905 (1-142) (HBA_HUMAN)search Homo sapienssearch 98% 142 95%
D Hemoglobin alpha chain P69905 (1-142) (HBA_HUMAN)search Homo sapienssearch 98% 142 95%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q9NZD4 (1 - 102) Alpha-hemoglobin stabilizing protein Homo sapiens
P69905 (1 - 142) Hemoglobin alpha chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (Q9NZD4) Alpha-hemoglobin stabilizing protein AHSPsearch Alpha-hemoglobin stabilizing proteinsearch PF09236: Alpha-haemoglobin stabilising proteinsearch
B, D (P69905) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, C (Q9NZD4) hemoglobin metabolic processsearch protein foldingsearch hemopoiesissearch protein stabilizationsearch hemoglobin bindingsearch unfolded protein bindingsearch cytoplasmsearch hemoglobin complexsearch
B, D (P69905) oxygen transportsearch protein heterooligomerizationsearch transportsearch hydrogen peroxide catabolic processsearch oxidation-reduction processsearch bicarbonate transportsearch response to hydrogen peroxidesearch positive regulation of cell deathsearch small molecule metabolic processsearch heme bindingsearch iron ion bindingsearch oxygen bindingsearch metal ion bindingsearch peroxidase activitysearch protein bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch hemoglobin complexsearch extracellular regionsearch cytosolsearch extracellular vesicular exosomesearch blood microparticlesearch cytosolic small ribosomal subunitsearch endocytic vesicle lumensearch membranesearch haptoglobin-hemoglobin complexsearch

Chain InterPro annotation
A, C Alpha-haemoglobin stabilising proteinsearch
B, D Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch