1z4y Summary


Parainfluenza Virus 5 (SV5) Hemagglutinin-Neuraminidase (HN) (pH 8.0)

The structure was published by Yuan, P., Thompson, T.B., Wurzburg, B.A., Paterson, R.G., Lamb, R.A., and Jardetzky, T.S., in 2005 in a paper entitled "Structural studies of the parainfluenza virus 5 hemagglutinin-neuraminidase tetramer in complex with its receptor, sialyllactose." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Hemagglutinin-neuraminidase. This molecule has the UniProt identifier P04850 (HN_SV5)search. The sample contained 532 residues which is 94% of the natural sequence. Out of 532 residues 442 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemagglutinin-neuraminidase P04850 (37-565) (HN_SV5)search Simian virus 5 (strain W3)search 90% 532 83%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P04850 (37 - 565) Hemagglutinin-neuraminidase Parainfluenza virus 5

Chain Sequence family (Pfam)
A (P04850) PF00423: Haemagglutinin-neuraminidasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P04850) metabolic processsearch viral processsearch viral life cyclesearch virion attachment to host cellsearch viral entry into host cellsearch exo-alpha-sialidase activitysearch host cell surface receptor bindingsearch hydrolase activitysearch exo-alpha-(2->6)-sialidase activitysearch exo-alpha-(2->3)-sialidase activitysearch exo-alpha-(2->8)-sialidase activitysearch viral envelopesearch virionsearch integral component of membranesearch host cell membranesearch membranesearch host cell plasma membranesearch virion membranesearch

Chain InterPro annotation
A Haemagglutinin-neuraminidasesearch Sialidasessearch Haemagglutinin-neuraminidase, paramyxovirussearch