› 1z27

X-ray diffraction
2.08Å resolution

Crystal structure of Native Pvs25, an ookinete protein from Plasmodium vivax.

Released:
DOI: 10.2210/pdb1z27/pdb
PDB entry 1z27 coloured by chain, front view.
PDB entry 1z27 coloured by chain, side view.
PDB entry 1z27 coloured by chain, top view.
Source organism: Plasmodium vivax
Primary publication:
The essential mosquito-stage P25 and P28 proteins from Plasmodium form tile-like triangular prisms.
Saxena AK, Singh K, Su HP, Klein MM, Stowers AW, Saul AJ, Long CA, Garboczi DN
Nat Struct Mol Biol 13 90-1 (2006)
PMID: 16327807

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132151 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
EGF-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 186 amino acids
Theoretical weight: 20.55 KDa
Source organism: Plasmodium vivax
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: O96555 (Residues: 23-197; Coverage: 89%)
Gene name: Pvs25
Sequence domains: Pvs28 EGF domain
Structure domains: Plasmodium vivax P25 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 42.611Å b: 59.805Å c: 66.747Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.258 0.258 0.267
Expression system: Saccharomyces cerevisiae

Quick links

Citations

12 review citations

Mosquito stage, transmission blocking vaccines for malaria.
Saul A. (2007)
11 more

2 mentions without citation

Enhancing immunogenicity and transmission-blocking activity of malaria vaccines by fusing Pfs25 to IMX313 multimerization technology.
Li et al. (2016)
1 more