1z26 Summary


Structure of Pyrococcus furiosus Argonaute with bound tungstate

The structure was published by Rivas, F.V., Tolia, N.H., Song, J.J., et al., Liu, J., Hannon, G.J., and Joshua-Tor, L., in 2005 in a paper entitled "Purified Argonaute2 and an siRNA form recombinant human RISC." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Argonaute. This molecule has the UniProt identifier Q8U3D2 (Q8U3D2_PYRFU)search. The sample contained 771 residues which is 100% of the natural sequence. Out of 771 residues 716 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Argonaute Q8U3D2 (1-770) (Q8U3D2_PYRFU)search Pyrococcus furiosus DSM 3638search 100% 771 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q8U3D2 (1 - 770) Argonaute Pyrococcus furiosus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (Q8U3D2) PAZ domainsearch, PIWI domainsearch Rossmann foldsearch, Nucleotidyltransferase; domain 5search PF02171: Piwi domainsearch, PF12212: Piwi/Argonaute/Zwille siRNA-binding domainsearch

Chain ID Molecular function (GO)
A (Q8U3D2) metal ion bindingsearch nucleic acid bindingsearch

Chain InterPro annotation
A PAZ domainsearch Piwi domainsearch Ribonuclease H-like domainsearch siRNA-binding, Argonautesearch