1yzx Summary


Crystal structure of human kappa class glutathione transferase

The structure was published by Li, J., Xia, Z., and Ding, J., in 2005 in a paper entitled "Thioredoxin-like domain of human kappa class glutathione transferase reveals sequence homology and structure similarity to the theta class enzyme" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.93 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glutathione S-transferase kappa 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glutathione S-transferase kappa 1 Q9Y2Q3 (1-226) (GSTK1_HUMAN)search Homo sapienssearch 100% 226 96%
B Glutathione S-transferase kappa 1 Q9Y2Q3 (1-226) (GSTK1_HUMAN)search Homo sapienssearch 100% 226 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9Y2Q3 (1 - 226) Glutathione S-transferase kappa 1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (Q9Y2Q3) Glutaredoxinsearch PF01323: DSBA-like thioredoxin domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (Q9Y2Q3) protein disulfide oxidoreductase activitysearch glutathione transferase activitysearch glutathione peroxidase activitysearch receptor bindingsearch transferase activitysearch intracellularsearch mitochondrial inner membranesearch peroxisomesearch extracellular vesicular exosomesearch membranesearch mitochondrial matrixsearch mitochondrionsearch oxidation-reduction processsearch glutathione metabolic processsearch epithelial cell differentiationsearch

Chain InterPro annotation
A, B DSBA-like thioredoxin domainsearch Thioredoxin-like foldsearch HCCA isomerase/glutathione S-transferase kappasearch