1yzi Summary

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A novel quaternary structure of human carbonmonoxy hemoglobin

The structure was published by Safo, M.K. and Abraham, D.J., in 2005 in a paper entitled "The enigma of the liganded hemoglobin end state: a novel quaternary structure of human carbonmonoxy hemoglobin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.07 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P69905) oxygen bindingsearch oxygen transporter activitysearch heme bindingsearch protein bindingsearch metal ion bindingsearch peroxidase activitysearch haptoglobin bindingsearch iron ion bindingsearch hemoglobin complexsearch endocytic vesicle lumensearch extracellular regionsearch cytosolsearch extracellular vesicular exosomesearch membranesearch cytosolic small ribosomal subunitsearch blood microparticlesearch haptoglobin-hemoglobin complexsearch small molecule metabolic processsearch positive regulation of cell deathsearch bicarbonate transportsearch oxidation-reduction processsearch response to hydrogen peroxidesearch transportsearch oxygen transportsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch
B (P68871) heme bindingsearch protein bindingsearch peroxidase activitysearch oxygen transporter activitysearch oxygen bindingsearch hemoglobin bindingsearch haptoglobin bindingsearch iron ion bindingsearch metal ion bindingsearch extracellular regionsearch cytosolsearch hemoglobin complexsearch extracellular vesicular exosomesearch blood microparticlesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch oxygen transportsearch bicarbonate transportsearch oxidation-reduction processsearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch nitric oxide transportsearch small molecule metabolic processsearch platelet aggregationsearch protein heterooligomerizationsearch blood coagulationsearch positive regulation of nitric oxide biosynthetic processsearch renal absorptionsearch regulation of blood vessel sizesearch regulation of blood pressuresearch positive regulation of cell deathsearch transportsearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch