1yzb Summary

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Solution structure of the Josephin domain of Ataxin-3

The structure was published by Nicastro, G., Menon, R.P., Masino, L., Knowles, P.P., McDonald, N.Q., and Pastore, A., in 2005 in a paper entitled "The solution structure of the Josephin domain of ataxin-3: Structural determinants for molecular recognition" (abstract).

The structure was determined using NMR spectroscopy and deposited in 2005.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Machado-Joseph disease protein 1. This molecule has the UniProt identifier P54252 (ATX3_HUMAN)search. The sample contained 182 residues which is < 90% of the natural sequence. Out of 182 residues 182 were observed and are deposited in the PDB.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Machado-Joseph disease protein 1 P54252 (1-182) (ATX3_HUMAN)search Homo sapienssearch < 90% 182 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P54252 (1 - 182) Machado-Joseph disease protein 1 Homo sapiens

Chain Sequence family (Pfam)
A Josephinsearch

Chain ID Molecular function (GO)
A (P54252) omega peptidase activitysearch

Chain InterPro annotation
A Machado-Joseph disease protein MJDsearch