1yye Summary

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Crystal structure of estrogen receptor beta complexed with way-202196

The structure was published by Mewshaw, R.E., Edsall Jr., R.J., Yang, C., et al., Henderson, R.A., Keith Jr., J.C., and Harris, H.A., in 2005 in a paper entitled "ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.03 Å and deposited in 2005.

The experimental data on which the structure is based was not deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Estrogen receptor beta and STEROID RECEPTOR COACTIVATOR-1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Estrogen receptor beta Q92731 (263-530) (ESR2_HUMAN)search Homo sapienssearch < 90% 268 85%
B Estrogen receptor beta Q92731 (263-530) (ESR2_HUMAN)search Homo sapienssearch < 90% 268 85%
C STEROID RECEPTOR COACTIVATOR-1 Not available
Synthetic Not available 13 76%
D STEROID RECEPTOR COACTIVATOR-1 Not available
Synthetic Not available 13 76%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q92731 (263 - 530) Estrogen receptor beta Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B Nuclear receptor ligand-binding domainsearch Retinoid X Receptorsearch Ligand-binding domain of nuclear hormone receptorsearch
C, D

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B (Q92731) regulation of transcription, DNA-templatedsearch steroid hormone mediated signaling pathwaysearch nucleussearch sequence-specific DNA binding transcription factor activitysearch steroid hormone receptor activitysearch DNA bindingsearch

Chain InterPro annotation
A, B Nuclear hormone receptor, ligand-binding, coresearch Steroid hormone receptorsearch Nuclear hormone receptor, ligand-bindingsearch
C, D