1yy9 Summary

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Structure of the extracellular domain of the epidermal growth factor receptor in complex with the Fab fragment of cetuximab/Erbitux/IMC-C225

The structure was published by Li, S., Schmitz, K.R., Jeffrey, P.D., Wiltzius, J.J.W., Kussie, P., and Ferguson, K.M., in 2005 in a paper entitled "Structural basis for inhibition of the epidermal growth factor receptor by cetuximab" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.605 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Epidermal Growth Factor Receptor, Cetuximab Fab Light chain, and Cetuximab Fab Heavy chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Epidermal Growth Factor Receptor P00533 (25-642) (EGFR_HUMAN)search Homo sapienssearch < 90% 624 98%
C Cetuximab Fab Light chain Not available
Mus musculussearch, Homo sapienssearch Not available 213 99%
D Cetuximab Fab Heavy chain Not available
Mus musculussearch, Homo sapienssearch Not available 221 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00533 (25 - 642) Epidermal Growth Factor Receptor Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A L domainsearch, Growth factor receptor domainsearch 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'. Chain A, domain 1search, Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2search Furin-like cysteine rich regionsearch, Receptor L domainsearch, Growth factor receptor domain IVsearch
C Immunoglobulinssearch
D Immunoglobulinssearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P00533) protein phosphorylationsearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch transmembrane receptor protein tyrosine kinase activitysearch ATP bindingsearch membranesearch

Chain InterPro annotation
A Receptor L-domainsearch Furin-like cysteine-rich domainsearch Furin-like repeatsearch Insulin-like growth factor binding protein, N-terminalsearch
C Immunoglobulin/major histocompatibility complex, conserved sitesearch search Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch
D Immunoglobulin/major histocompatibility complex, conserved sitesearch search Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch