Structure of the extracellular domain of the epidermal growth factor receptor in complex with the Fab fragment of cetuximab/Erbitux/IMC-C225
The structure was published by Li, S., Schmitz, K.R., Jeffrey, P.D., Wiltzius, J.J.W., Kussie, P., and Ferguson, K.M., in 2005 in a paper entitled "Structural basis for inhibition of the epidermal growth factor receptor by cetuximab" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.605 Å and deposited in 2005.
The experimental data on which the structure is based was also deposited.
This PDB entry contains a complex of 3 biomacromolecules, namely Epidermal Growth Factor Receptor, Cetuximab Fab Light chain, and Cetuximab Fab Heavy chain.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule most likely forms heterotrimers.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: