1yxx Summary

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Crystal Structure of Kinase Pim1 in complex with (3E)-3-[(4-HYDROXYPHENYL)IMINO]-1H-INDOL-2(3H)-ONE

The structure was published by Kumar, A., Mandiyan, V., Suzuki, Y., et al., Artis, D.R., Ibrahim, P., and Bremer, R., in 2005 in a paper entitled "Crystal Structures of Proto-oncogene Kinase Pim1: A Target of Aberrant Somatic Hypermutations in Diffuse Large Cell Lymphoma." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Proto-oncogene serine/threonine-protein kinase Pim-1. This molecule has the UniProt identifier P11309 (PIM1_HUMAN)search. The sample contained 293 residues which is < 90% of the natural sequence. Out of 293 residues 274 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Proto-oncogene serine/threonine-protein kinase Pim-1 P11309 (120-404) (PIM1_HUMAN)search Homo sapienssearch < 90% 293 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P11309 (120 - 404) Proto-oncogene serine/threonine-protein kinase Pim-1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (P11309) ATP bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch