1ywv Summary

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Crystal Structures of Proto-Oncogene Kinase Pim1: a Target of Aberrant Somatic Hypermutations in Diffuse Large Cell Lymphoma

The structure was published by Kumar, A., Mandiyan, V., Suzuki, Y., et al., Artis, D.R., Ibrahim, P., and Bremer, R., in 2005 in a paper entitled "Crystal Structures of Proto-oncogene Kinase Pim1: A Target of Aberrant Somatic Hypermutations in Diffuse Large Cell Lymphoma." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Proto-oncogene serine/threonine-protein kinase Pim-1. This molecule has the UniProt identifier P11309 (PIM1_HUMAN)search. The sample contained 293 residues which is < 90% of the natural sequence. Out of 293 residues 274 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Proto-oncogene serine/threonine-protein kinase Pim-1 P11309 (120-404) (PIM1_HUMAN)search Homo sapienssearch < 90% 293 93%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P11309 (120 - 404) Proto-oncogene serine/threonine-protein kinase Pim-1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A (P11309) protein phosphorylationsearch ATP bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch