1ywr Summary


Crystal Structure Analysis of inactive P38 kinase domain in complex with a Monocyclic Pyrazolone Inhibitor

The structure was published by Golebiowski, A., Townes, J.A., Laufersweiler, M.J., et al., Walter, R.L., Webster, M.E., and Mekel, M.J., in 2005 in a paper entitled "The development of monocyclic pyrazolone based cytokine synthesis inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier P47811 (MK14_MOUSE)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 337 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 P47811 (1-360) (MK14_MOUSE)search Mus musculussearch 97% 360 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P47811 (1 - 360) Mitogen-activated protein kinase 14 Mus musculus

Chain Structural classification (CATH) Sequence family (Pfam)
A (P47811) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P47811) MAP kinase activitysearch kinase activitysearch transferase activitysearch protein bindingsearch nucleotide bindingsearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch NFAT protein bindingsearch protein serine/threonine kinase activitysearch cellular response to lipopolysaccharidesearch stress-induced premature senescencesearch positive regulation of myoblast fusionsearch intracellular signal transductionsearch response to stresssearch chondrocyte differentiationsearch fatty acid oxidationsearch lipopolysaccharide-mediated signaling pathwaysearch protein phosphorylationsearch DNA damage checkpointsearch myoblast differentiation involved in skeletal muscle regenerationsearch cellular response to vascular endothelial growth factor stimulussearch negative regulation of canonical Wnt signaling pathwaysearch cellular response to DNA damage stimulussearch regulation of transcription from RNA polymerase II promotersearch angiogenesissearch signal transduction in response to DNA damagesearch phosphorylationsearch regulation of transcription, DNA-templatedsearch positive regulation of protein import into nucleussearch positive regulation of erythrocyte differentiationsearch positive regulation of myotube differentiationsearch cellular response to ionizing radiationsearch positive regulation of transcription from RNA polymerase II promotersearch transcription, DNA-templatedsearch apoptotic processsearch peptidyl-serine phosphorylationsearch skeletal muscle tissue developmentsearch positive regulation of reactive oxygen species metabolic processsearch p38MAPK cascadesearch vascular endothelial growth factor receptor signaling pathwaysearch osteoclast differentiationsearch response to lipopolysaccharidesearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch positive regulation of myoblast differentiationsearch striated muscle cell differentiationsearch cell morphogenesissearch cartilage condensationsearch glucose metabolic processsearch response to muramyl dipeptidesearch cytoplasmsearch nucleussearch extracellular vesicular exosomesearch cytosolsearch spindle polesearch mitochondrionsearch cellsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch