Crystal Structure Analysis of inactive P38 kinase domain in complex with a Monocyclic Pyrazolone Inhibitor
The structure was published by Golebiowski, A., Townes, J.A., Laufersweiler, M.J., et al., Walter, R.L., Webster, M.E., and Mekel, M.J., in 2005 in a paper entitled "The development of monocyclic pyrazolone based cytokine synthesis inhibitors." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2005.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier P47811 (MK14_MOUSE). The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 337 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: