Function and Biology Details
Reaction catalysed:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145422 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Molecule details ›
Chain: A
Length: 64 amino acids
Theoretical weight: 7.41 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: SH3 domain
Structure domains: SH3 Domains
Length: 64 amino acids
Theoretical weight: 7.41 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P10686 (Residues: 790-851; Coverage: 5%)
Sequence domains: SH3 domain
Structure domains: SH3 Domains
Lymphocyte cytosolic protein 2
Molecule details ›
Chain: P
Length: 10 amino acids
Theoretical weight: 1.15 KDa
Source organism: Homo sapiens
UniProt:
Length: 10 amino acids
Theoretical weight: 1.15 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: Q13094 (Residues: 185-194; Coverage: 2%)
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
NSLS BEAMLINE X29A
Spacegroup:
P43212
Expression system: Escherichia coli BL21(DE3)
