1ywo Summary


Phospholipase Cgamma1 SH3 in complex with a SLP-76 motif

The structure was published by Deng, L., Velikovsky, C.A., Swaminathan, C.P., Cho, S., and Mariuzza, R.A., in 2005 in a paper entitled "Structural Basis for Recognition of the T Cell Adaptor Protein SLP-76 by the SH3 Domain of Phospholipase Cgamma1" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.81 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 and Lymphocyte cytosolic protein 2.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 P10686 (790-851) (PLCG1_RAT)search Rattus norvegicussearch < 90% 64 85%
P Lymphocyte cytosolic protein 2 Q13094 (185-194) (LCP2_HUMAN)search Homo sapienssearch < 90% 10 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P10686 (790 - 851) 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 Rattus norvegicus
Q13094 (185 - 194) Lymphocyte cytosolic protein 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A SH3 Domainssearch SH3 domainsearch
Chain InterPro annotation
A SH3 domainsearch