1ywn Summary

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Vegfr2 in complex with a novel 4-amino-furo[2,3-d]pyrimidine

The structure was published by Miyazaki, Y., Matsunaga, S., Tang, J., et al., Sato, H., Wang, L., and Nolte, R.T., in 2005 in a paper entitled "Novel 4-amino-furo[2,3-d]pyrimidines as Tie-2 and VEGFR2 dual inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.71 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Vascular endothelial growth factor receptor 2. This molecule has the UniProt identifier P35968 (VGFR2_HUMAN)search. The sample contained 316 residues which is < 90% of the natural sequence. Out of 316 residues 280 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Vascular endothelial growth factor receptor 2 P35968 (806-1171) (VGFR2_HUMAN)search Homo sapienssearch < 90% 316 88%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35968 (806 - 1171) Vascular endothelial growth factor receptor 2 Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Protein kinases, catalytic subunitsearch Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P35968) protein kinase activitysearch transmembrane receptor protein tyrosine kinase activitysearch ATP bindingsearch protein tyrosine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch growth factor bindingsearch vascular endothelial growth factor-activated receptor activitysearch membranesearch integral component of membranesearch vascular endothelial growth factor receptor signaling pathwaysearch protein phosphorylationsearch transmembrane receptor protein tyrosine kinase signaling pathwaysearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, receptor class III, conserved sitesearch Tyrosine-protein kinase, active sitesearch Vascular endothelial growth factor receptor 2 (VEGFR2)search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch