1yvt Summary

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The high salt (phosphate) crystal structure of CO Hemoglobin E (Glu26Lys) at physiological pH (pH 7.35)

A publication describing this structure is not available. The depositing authors are Malashkevich, V.N.search; Balazs, T.C.search; Almo, S.C.search; Hirsch, R.E.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P69905) hemoglobin complexsearch cytosolsearch blood microparticlesearch membranesearch extracellular regionsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch cytosolic small ribosomal subunitsearch heme bindingsearch iron ion bindingsearch oxygen transporter activitysearch protein bindingsearch peroxidase activitysearch metal ion bindingsearch haptoglobin bindingsearch oxygen bindingsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch oxygen transportsearch transportsearch protein heterooligomerizationsearch oxidation-reduction processsearch response to hydrogen peroxidesearch receptor-mediated endocytosissearch small molecule metabolic processsearch positive regulation of cell deathsearch
B (P68871) hemoglobin complexsearch extracellular regionsearch cytosolsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch blood microparticlesearch oxygen bindingsearch heme bindingsearch metal ion bindingsearch protein bindingsearch peroxidase activitysearch haptoglobin bindingsearch oxygen transporter activitysearch iron ion bindingsearch hemoglobin bindingsearch transportsearch small molecule metabolic processsearch oxygen transportsearch bicarbonate transportsearch receptor-mediated endocytosissearch response to hydrogen peroxidesearch oxidation-reduction processsearch nitric oxide transportsearch positive regulation of cell deathsearch renal absorptionsearch platelet aggregationsearch blood coagulationsearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood vessel sizesearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch regulation of blood pressuresearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch