1yvt Summary

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The high salt (phosphate) crystal structure of CO Hemoglobin E (Glu26Lys) at physiological pH (pH 7.35)

A publication describing this structure is not available. The depositing authors are Malashkevich, V.N.search; Balazs, T.C.search; Almo, S.C.search; Hirsch, R.E.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P69905) bicarbonate transportsearch hydrogen peroxide catabolic processsearch response to hydrogen peroxidesearch protein heterooligomerizationsearch oxygen transportsearch small molecule metabolic processsearch positive regulation of cell deathsearch oxidation-reduction processsearch transportsearch peroxidase activitysearch protein bindingsearch metal ion bindingsearch iron ion bindingsearch oxygen bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch heme bindingsearch blood microparticlesearch hemoglobin complexsearch cytosolsearch membranesearch extracellular vesicular exosomesearch extracellular regionsearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch cytosolic small ribosomal subunitsearch
B (P68871) blood coagulationsearch regulation of blood pressuresearch oxidation-reduction processsearch small molecule metabolic processsearch oxygen transportsearch bicarbonate transportsearch response to hydrogen peroxidesearch nitric oxide transportsearch positive regulation of cell deathsearch regulation of blood vessel sizesearch positive regulation of nitric oxide biosynthetic processsearch platelet aggregationsearch transportsearch renal absorptionsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch peroxidase activitysearch oxygen transporter activitysearch protein bindingsearch heme bindingsearch iron ion bindingsearch metal ion bindingsearch haptoglobin bindingsearch hemoglobin bindingsearch oxygen bindingsearch hemoglobin complexsearch extracellular regionsearch cytosolsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch blood microparticlesearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch