1yvt Summary

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The high salt (phosphate) crystal structure of CO Hemoglobin E (Glu26Lys) at physiological pH (pH 7.35)

A publication describing this structure is not available. The depositing authors are Malashkevich, V.N.search; Balazs, T.C.search; Almo, S.C.search; Hirsch, R.E.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P69905) hemoglobin complexsearch blood microparticlesearch cytosolsearch extracellular regionsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch membranesearch haptoglobin-hemoglobin complexsearch cytosolic small ribosomal subunitsearch heme bindingsearch oxygen bindingsearch iron ion bindingsearch protein bindingsearch metal ion bindingsearch peroxidase activitysearch haptoglobin bindingsearch oxygen transporter activitysearch oxygen transportsearch hydrogen peroxide catabolic processsearch bicarbonate transportsearch protein heterooligomerizationsearch response to hydrogen peroxidesearch oxidation-reduction processsearch positive regulation of cell deathsearch small molecule metabolic processsearch transportsearch
B (P68871) hemoglobin complexsearch cytosolsearch extracellular regionsearch endocytic vesicle lumensearch extracellular vesicular exosomesearch blood microparticlesearch haptoglobin-hemoglobin complexsearch oxygen bindingsearch heme bindingsearch iron ion bindingsearch peroxidase activitysearch protein bindingsearch metal ion bindingsearch oxygen transporter activitysearch haptoglobin bindingsearch hemoglobin bindingsearch oxygen transportsearch regulation of blood vessel sizesearch small molecule metabolic processsearch blood coagulationsearch response to hydrogen peroxidesearch bicarbonate transportsearch transportsearch oxidation-reduction processsearch renal absorptionsearch positive regulation of cell deathsearch regulation of blood pressuresearch nitric oxide transportsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch positive regulation of nitric oxide biosynthetic processsearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch