1yvt Summary

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The high salt (phosphate) crystal structure of CO Hemoglobin E (Glu26Lys) at physiological pH (pH 7.35)

A publication describing this structure is not available. The depositing authors are Malashkevich, V.N.search; Balazs, T.C.search; Almo, S.C.search; Hirsch, R.E.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P69905) hemoglobin complexsearch blood microparticlesearch cytosolsearch extracellular regionsearch extracellular exosomesearch membranesearch endocytic vesicle lumensearch haptoglobin-hemoglobin complexsearch cytosolic small ribosomal subunitsearch oxygen bindingsearch heme bindingsearch protein bindingsearch peroxidase activitysearch metal ion bindingsearch iron ion bindingsearch haptoglobin bindingsearch oxygen transporter activitysearch oxygen transportsearch bicarbonate transportsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch response to hydrogen peroxidesearch oxidation-reduction processsearch receptor-mediated endocytosissearch transportsearch small molecule metabolic processsearch positive regulation of cell deathsearch
B (P68871) hemoglobin complexsearch cytosolsearch extracellular regionsearch extracellular exosomesearch endocytic vesicle lumensearch blood microparticlesearch haptoglobin-hemoglobin complexsearch heme bindingsearch oxygen transporter activitysearch peroxidase activitysearch protein bindingsearch iron ion bindingsearch haptoglobin bindingsearch oxygen bindingsearch hemoglobin bindingsearch metal ion bindingsearch oxygen transportsearch small molecule metabolic processsearch response to hydrogen peroxidesearch regulation of blood pressuresearch receptor-mediated endocytosissearch bicarbonate transportsearch transportsearch renal absorptionsearch platelet aggregationsearch nitric oxide transportsearch positive regulation of cell deathsearch oxidation-reduction processsearch positive regulation of nitric oxide biosynthetic processsearch regulation of blood vessel sizesearch blood coagulationsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch

Chain InterPro annotation
A Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch