1yvq Summary

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The low salt (PEG) crystal structure of CO Hemoglobin E (betaE26K) approaching physiological pH (pH 7.5)

A publication describing this structure is not available. The depositing authors are Malashkevich, V.N.search; Balazs, T.C.search; Almo, S.C.search; Hirsch, R.E.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, C (P69905) iron ion bindingsearch heme bindingsearch protein bindingsearch oxygen bindingsearch haptoglobin bindingsearch peroxidase activitysearch oxygen transporter activitysearch metal ion bindingsearch oxygen transportsearch response to hydrogen peroxidesearch bicarbonate transportsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch oxidation-reduction processsearch small molecule metabolic processsearch transportsearch hemoglobin complexsearch cytosolsearch extracellular vesicular exosomesearch extracellular regionsearch endocytic vesicle lumensearch blood microparticlesearch membranesearch haptoglobin-hemoglobin complexsearch cytosolic small ribosomal subunitsearch
B, D (P68871) heme bindingsearch oxygen bindingsearch iron ion bindingsearch protein bindingsearch metal ion bindingsearch oxygen transporter activitysearch peroxidase activitysearch haptoglobin bindingsearch hemoglobin bindingsearch oxygen transportsearch regulation of blood vessel sizesearch transportsearch renal absorptionsearch oxidation-reduction processsearch response to hydrogen peroxidesearch positive regulation of nitric oxide biosynthetic processsearch positive regulation of cell deathsearch nitric oxide transportsearch bicarbonate transportsearch small molecule metabolic processsearch blood coagulationsearch regulation of blood pressuresearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch cytosolsearch extracellular regionsearch blood microparticlesearch endocytic vesicle lumensearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch