1yvq Summary

pdbe.org/1yvq
spacer

The low salt (PEG) crystal structure of CO Hemoglobin E (betaE26K) approaching physiological pH (pH 7.5)

A publication describing this structure is not available. The depositing authors are Malashkevich, V.N.search; Balazs, T.C.search; Almo, S.C.search; Hirsch, R.E.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Hemoglobin alpha chain and Hemoglobin beta chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
C Hemoglobin alpha chain P69905 (2-142) (HBA_HUMAN)search Homo sapienssearch 98% 141 100%
B Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%
D Hemoglobin beta chain P68871 (2-147) (HBB_HUMAN)search Homo sapienssearch 98% 146 100%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P69905 (2 - 142) Hemoglobin alpha chain Homo sapiens
P68871 (2 - 147) Hemoglobin beta chain Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, C (P69905) Globinssearch Globinssearch PF00042: Globinsearch
B, D (P68871) Globinssearch Globinssearch PF00042: Globinsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, C (P69905) oxidation-reduction processsearch response to hydrogen peroxidesearch transportsearch oxygen transportsearch bicarbonate transportsearch small molecule metabolic processsearch positive regulation of cell deathsearch hydrogen peroxide catabolic processsearch protein heterooligomerizationsearch extracellular regionsearch cytosolsearch extracellular vesicular exosomesearch endocytic vesicle lumensearch cytosolic small ribosomal subunitsearch membranesearch blood microparticlesearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch protein bindingsearch haptoglobin bindingsearch heme bindingsearch iron ion bindingsearch oxygen bindingsearch peroxidase activitysearch oxygen transporter activitysearch metal ion bindingsearch
B, D (P68871) oxygen transportsearch small molecule metabolic processsearch response to hydrogen peroxidesearch renal absorptionsearch regulation of blood vessel sizesearch platelet aggregationsearch regulation of blood pressuresearch bicarbonate transportsearch positive regulation of cell deathsearch positive regulation of nitric oxide biosynthetic processsearch nitric oxide transportsearch transportsearch blood coagulationsearch oxidation-reduction processsearch protein heterooligomerizationsearch hydrogen peroxide catabolic processsearch hemoglobin complexsearch haptoglobin-hemoglobin complexsearch extracellular vesicular exosomesearch extracellular regionsearch cytosolsearch blood microparticlesearch endocytic vesicle lumensearch protein bindingsearch oxygen transporter activitysearch peroxidase activitysearch metal ion bindingsearch oxygen bindingsearch iron ion bindingsearch hemoglobin bindingsearch haptoglobin bindingsearch heme bindingsearch

Chain InterPro annotation
A, C Globinsearch Haemoglobin, alphasearch Haemoglobin, pisearch Globin-likesearch Globin, structural domainsearch
B, D Globinsearch Haemoglobin, betasearch Globin-likesearch Globin, structural domainsearch