1yvj Summary


Crystal structure of the Jak3 kinase domain in complex with a staurosporine analogue

The structure was published by Boggon, T.J., Li, Y., Manley, P.W., and Eck, M.J., in 2005 in a paper entitled "Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.55 Å and deposited in 2005.

The experimental data on which the structure is based was not deposited.

The PDB entry contains the structure of Tyrosine-protein kinase JAK3. This molecule has the UniProt identifier P52333 (JAK3_HUMAN)search. The sample contained 290 residues which is < 90% of the natural sequence. Out of 290 residues 288 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Tyrosine-protein kinase JAK3 P52333 (814-1103) (JAK3_HUMAN)search Homo sapienssearch < 90% 290 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P52333 (814 - 1103) Tyrosine-protein kinase JAK3 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (P52333) protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch ATP bindingsearch protein tyrosine kinase activitysearch protein phosphorylationsearch regulation of signal transductionsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch