1yvh Summary


Crystal Structure of the c-Cbl TKB Domain in Complex with the APS pTyr-618 Phosphopeptide

The structure was published by Hu, J. and Hubbard, S.R., in 2005 in a paper entitled "Structural Characterization of a Novel Cbl Phosphotyrosine Recognition Motif in the APS Family of Adapter Proteins" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.05 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely CBL E3 ubiquitin protein ligase and 13-mer fragment of SH2 and PH domain-containing adapter protein APS.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CBL E3 ubiquitin protein ligase P22681 (25-351) (CBL_HUMAN)search Homo sapienssearch < 90% 329 92%
B 13-mer fragment of SH2 and PH domain-containing adapter protein APS Q9Z200 (609-621) (SH2B2_RAT)search Rattus norvegicussearch < 90% 13 69%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P22681 (25 - 351) CBL E3 ubiquitin protein ligase Homo sapiens
Q9Z200 (609 - 621) 13-mer fragment of SH2 and PH domain-containing adapter protein APS

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A EF-hand modules in multidomain proteinssearch, N-terminal domain of cbl (N-cbl)search, SH2 domainsearch Transcription Elongation Factor S-II; Chain Asearch, EF-handsearch, SHC Adaptor Proteinsearch CBL proto-oncogene N-terminal domain 1search, CBL proto-oncogene N-terminus, EF hand-like domainsearch, CBL proto-oncogene N-terminus, SH2-like domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P22681) regulation of signalingsearch cell surface receptor signaling pathwaysearch calcium ion bindingsearch phosphotyrosine bindingsearch ubiquitin-protein transferase activitysearch signal transducer activitysearch nucleussearch

Chain InterPro annotation
A SH2 domainsearch Adaptor protein Cbl, N-terminal helicalsearch EF-hand domain pairsearch Adaptor protein Cbl, EF hand-likesearch Adaptor protein Cbl, SH2-likesearch Adaptor protein Cbl, PTB domainsearch Adaptor protein Cblsearch