1yvb Summary


the Plasmodium falciparum Cysteine Protease Falcipain-2

There is a Quite Interesting Protein Structure article for this entry.

The structure was published by Wang, S.X., Pandey, K.C., Somoza, J.R., et al., Fletterick, R.J., Rosenthal, P.J., and McKerrow, J.H., in 2006 in a paper entitled "Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.7 Å and deposited in 2005.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely falcipain 2 and Cystatin.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A falcipain 2 Q9N6S8 (244-484) (Q9N6S8_PLAFA)search Plasmodium falciparumsearch < 90% 241 100%
I Cystatin P01038 (29-139) (CYT_CHICK)search Gallus gallussearch 93% 111 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q9N6S8 (244 - 484) falcipain 2 Plasmodium falciparum 3D7
P01038 (29 - 139) Cystatin Gallus gallus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A Papain-likesearch Cysteine proteinasessearch Papain family cysteine proteasesearch
I (P01038) Cystatinssearch Nuclear Transport Factor 2; Chain: A,search PF00031: Cystatin domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q9N6S8) cysteine-type peptidase activitysearch proteolysissearch
I (P01038) cysteine-type endopeptidase inhibitor activitysearch peptidase inhibitor activitysearch negative regulation of peptidase activitysearch negative regulation of endopeptidase activitysearch extracellular regionsearch

Chain InterPro annotation
A Cysteine peptidase, cysteine active sitesearch Peptidase C1A, papain C-terminalsearch Peptidase C1Asearch Cysteine peptidase, histidine active sitesearch
I Proteinase inhibitor I25, cystatinsearch Proteinase inhibitor I25, cystatin, conserved sitesearch Cystatinsearch